2-Minute Neuroscience: Methylphenidate

Methylphenidate is believed to work by blocking the reuptake of dopamine and norepinephrine by neurons. It is a central nervous system (CNS) stimulant of the ...

While its exact mechanism is unclear, methylphenidate (MPH) has been shown to act as a norepinephrine and dopamine reuptake inhibitor (NDRI), thereby increasing ...

由 J Quintero 著作 · 2022 · 被引用 14 次 — Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action.

2015年1月23日 — Methylphenidate inhibits the reuptake of dopamine and norepinephrine, increased dopaminergic and noradrenergic activity in the prefrontal cortex ...

由 TD Challman 著作 · 2000 · 被引用 457 次 — It was subsequently shown that methylphenidate binds to the dopamine transporter in the presynaptic cell membrane, blocking reuptake of dopamine and causing a ...

由 SV Faraone 著作 · 2018 · 被引用 485 次 — Methylphenidate actions include dopamine and norepinephrine transporter inhibition, agonist activity at the serotonin type 1A receptor, and ...

由 C Verghese 著作 · 2022 · 被引用 22 次 — Mechanism of Action ... With the increase in dopamine levels, methylphenidate can provide neuroprotection in certain conditions like Parkinson ...